Smart polymers are engineered materials with programmable physical and chemical properties tailored for specific uses. The range of applications for such materials is vast, and one of the most prominent uses is targeted drug delivery, offering enhanced therapeutic efficacy, reduced side effects, and improved patient outcomes.

This study investigates a dual-polymeric system composed of diblock amphiphile (DBA) and triblock amphiphile (TBA), both enzymatically degradable. We examined how the variations in the two amphiphilic block-copolymers ratios, enzyme concentration, and albumin levels influence the system’s self-assembly properties and degradation kinetics. Our study provides new insights into the behavior and properties of the system, its transition from micelles to gel and the impact of albumin on the enzymatic degradation. Our research establishes a foundational understanding of the dual-polymeric self-assembly and paves the way for optimizing smart drug delivery systems for biomedical applications.